Rho-associated protein kinase 1 (IPR029876)

Short name: ROCK1

Overlapping homologous superfamilies


Family relationships



Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions [PMID: 23601011]. Two ROCK isoforms have been identified: ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [PMID: 23950574, PMID: 19907920, PMID: 20803696].

This entry represents ROCK1. ROCK1 is essential for the formation of stress fibres [PMID: 16043513].

GO terms

Biological Process

GO:0007266 Rho protein signal transduction
GO:0051493 regulation of cytoskeleton organization
GO:2000114 regulation of establishment of cell polarity
GO:0051492 regulation of stress fiber assembly

Molecular Function

GO:0017049 GTP-Rho binding
GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.