StAR-related lipid transfer protein 3, C-terminal (IPR029867)

Short name: STARD3_MLN64_C

Overlapping homologous superfamilies

Domain relationships

  • START domain (IPR002913)
    • StAR-related lipid transfer protein 3, C-terminal (IPR029867)


StAR-related lipid transfer protein 3 (STARD3, also known as MLN64) is an integral membrane protein localised to the late endosome and plasma membrane. It may function as a mediator of cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria [PMID: 16709157, PMID: 11053434, PMID: 19965586, PMID: 23028046]. It contains an N-terminal membrane-spanning domain that shares homology with the MENTHO protein and a C-terminal steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain that binds lipids, including sterols [PMID: 16709157]. Its transport to the late endosome is regulated by binding to 14-3-3 [PMID: 22514632].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity

Cellular Component

GO:0005770 late endosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.