Family

Basic leucine zipper transcriptional factor ATF-like 2 (IPR029857)

Short name: BATF2

Family relationships

None.

Description

Basic leucine zipper transcriptional factor ATF-like 2 (BATF2, also known as SARI) belongs to the activator protein 1 (AP-1) family of transcription factors. BATF2 selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61. It inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma [PMID: 20531301]. BATF2 is also induced by cytokines in response to infection acting as an important positive transcriptional regulator in the immune system [PMID: 22992524, PMID: 23787991].

GO terms

Biological Process

GO:0006357 regulation of transcription from RNA polymerase II promoter

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER