Sodium-dependent phosphate transport protein 2C (IPR029850)

Short name: Na/Pi_transpt_2C

Overlapping homologous superfamilies


Family relationships


The sodium-phosphate cotransporter type 2C (NPT2C, also known as SLC34A3) is found in the renal brush border membrane and is involved in maintaining phosphate homeostasis [PMID: 16358214]. It could function as a Na/P cotransporter in weaning animals, but its role is reduced in adults [PMID: 11880379], where type 2A is the main transporter [PMID: 19190675]. Mutations in the SLC34A3 gene cause a disease called hereditary hypophosphatemic rickets with hypercalcuria (HHRH), which is characterised by reduced renal phosphate reabsorption, hypophosphatemia, and rickets [PMID: 16358215]. However, no major phenotype could be detected in SLC34A3 knock-out mice [PMID: 19056871].

GO terms

Biological Process

GO:0044341 sodium-dependent phosphate transport

Molecular Function

GO:0015321 sodium-dependent phosphate transmembrane transporter activity

Cellular Component

GO:0031526 brush border membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.