Nuclear factor erythroid 2-related factor 2 (IPR029845)

Short name: Nrf2

Overlapping homologous superfamilies


Family relationships



Nuclear factor erythroid 2-related factor 2 (Nrf2) belongs to the CNC-bZIP family, which is a group of transcription factors that are activated in response to cellular stress. It binds to antioxidant response (ARE) elements in the promoter regions of target genes [PMID: 11035812]. It is constitutively and ubiquitously expressed in a number of tissues and cell lines. When exposed to oxidative stress, the expression of Nrf2 increases, further driving the transcriptional activation of genes that control cellular redox homeostasis [PMID: 15256215]. Nrf2 is regulated by the repressor protein Keap1, which acts by directly interacting with Nrf2 and preventing its nuclear accumulation [PMID: 15256215]. Keap1 not only acts to retain Nrf2 in the cytoplasm but also actively promotes its ubiquitylation and subsequent degradation by the proteasome.

GO terms

Biological Process

GO:0034599 cellular response to oxidative stress

Molecular Function

GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.