Cyclin-dependent kinase inhibitor 1B (IPR029843)

Short name: CDKN1B

Overlapping homologous superfamilies


Family relationships


Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27Kip1) controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks) [PMID: 17254966]. It is also involved in cell migration through binding and regulation of RhoA or stathmin [PMID: 18354415, PMID: 18267085, PMID: 15652749]. It also inhibits DNA replication by binding to the DNA replication licensing factor MCM7 [PMID: 16289477].

GO terms

Biological Process

GO:0042127 regulation of cell proliferation

Molecular Function

GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.