Cyclin-dependent kinase inhibitor 1C (IPR029842)
Short name: CDKN1C
Overlapping homologous superfamilies
- Cyclin-dependent kinase inhibitor (IPR003175)
- Cyclin-dependent kinase inhibitor 1C (IPR029842)
Cyclin-dependent kinase inhibitor 1C (CDKN1C, also known p57Kip2) is a cyclin-dependent kinase inhibitor that inhibits cell-cycle progression [PMID: 7729683, PMID: 11218061]. CDKN1C contains a PCNA-binding domain. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome, which is an undergrowth developmental disorder with life-threatening consequences [PMID: 22735584].
- PTHR10265:SF7 (PTHR10265:SF7)