Cyclin-dependent kinase inhibitor 1, vertebrate (IPR029841)

Short name: CDKN1A_vertebrate

Overlapping homologous superfamilies


Family relationships


This entry represents the cyclin-dependent kinase inhibitor 1 (CDKN1A, also known as p21) from vertebrates. It is a direct transcriptional target of p53 and may repress apoptosis [PMID: 25024194]. It mediates several important physiological effects of p53, including DNA-damage-induced cell cycle checkpoints [PMID: 25024194, PMID: 7585571]. p21 plays a critical role in regulating cell growth and the cell response to DNA damage [PMID: 10858953].

GO terms

Biological Process

GO:0007346 regulation of mitotic cell cycle
GO:0072331 signal transduction by p53 class mediator

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.