Cyclin-dependent kinase inhibitor 1, vertebrate (IPR029841)
Short name: CDKN1A_vertebrate
Overlapping homologous superfamilies
- Cyclin-dependent kinase inhibitor (IPR003175)
- Cyclin-dependent kinase inhibitor 1, vertebrate (IPR029841)
This entry represents the cyclin-dependent kinase inhibitor 1 (CDKN1A, also known as p21) from vertebrates. It is a direct transcriptional target of p53 and may repress apoptosis [PMID: 25024194]. It mediates several important physiological effects of p53, including DNA-damage-induced cell cycle checkpoints [PMID: 25024194, PMID: 7585571]. p21 plays a critical role in regulating cell growth and the cell response to DNA damage [PMID: 10858953].
- PTHR10265:SF16 (PTHR10265:SF16)