Zinc finger protein Gfi-1/1b (IPR029840)

Short name: GFI1/1B

Family relationships



Zinc finger protein Gfi-1 and Gfi-1b (growth factor independence-1B) are transcriptional regulators. They alter histone methylation by recruiting histone methyltransferase to target genes promoters and plays a role in heterochromatin formation [PMID: 16688220, PMID: 18805794]. In humans Gfi-1b is necessary for development and differentiation of erythroid and megakaryocytic lineages [PMID: 12351384, PMID: 20861919]. Gfi-1 plays a crucial role in hematopoietic, inner ear, and pulmonary neuroendocrine cell development and governs cell processes such as cell proliferation, apoptosis and differentiation [PMID: 16287849].

GO terms

Biological Process

GO:0030097 hemopoiesis
GO:0051569 regulation of histone H3-K4 methylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.