Family

Zinc finger protein Gfi-1/1b (IPR029840)

Short name: GFI1/1B

Family relationships

None.

Description

Zinc finger protein Gfi-1 and Gfi-1b (growth factor independence-1B) are transcriptional regulators. They alter histone methylation by recruiting histone methyltransferase to target genes promoters and plays a role in heterochromatin formation [PMID: 16688220, PMID: 18805794]. In humans Gfi-1b is necessary for development and differentiation of erythroid and megakaryocytic lineages [PMID: 12351384, PMID: 20861919]. Gfi-1 plays a crucial role in hematopoietic, inner ear, and pulmonary neuroendocrine cell development and governs cell processes such as cell proliferation, apoptosis and differentiation [PMID: 16287849].

GO terms

Biological Process

GO:0030097 hemopoiesis
GO:0051569 regulation of histone H3-K4 methylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER