Signal transducer and activator of transcription 4 (IPR029839)

Short name: STAT4

Overlapping homologous superfamilies


Family relationships


Signal transducer and activator of transcription 4 (STAT4) transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes [PMID: 15546391, PMID: 12213961]. It plays an important role in CD4+ Th1 lineage differentiation and IFN-gamma protein expression by CD4+ T cells [PMID: 24920804]. It is crucial for both innate and adaptive immune responses to viral infection [PMID: 24920804]. Variations of the STAT4 gene affect the susceptibility to autoimmune diseases [PMID: 18682104], such as systemic lupus erythematosus 11 (SLEB11) [PMID: 19109131] and rheumatoid arthritis (RA) [PMID: 17804842].

STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins [PMID: 12209125]. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes [PMID: 14668806]. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an alpha-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [PMID: 23977103].

GO terms

Biological Process

GO:0019221 cytokine-mediated signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA binding transcription factor activity
GO:0004871 signal transducer activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.