Family

CUB and zona pellucida-like domain-containing protein 1 (IPR029834)

Short name: Cuzd1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

CUB and zona pellucida-like domain-containing protein 1 (CUZD1) may play a role in the uterus during late pregnancy [PMID: 9480914]. Silencing expression of CUZD1 sensitises human ovarian cancer cells to the treatment drug cisplatin [PMID: 16862170]. This and other data strongly support a role for CUZD1 in carcinogenesis [PMID: 23710207]. Furthermore, CUZD1 is an antigen of pancreatic autoantibodies (PAB) in patients with inflammatory bowel diseases [PMID: 23710207].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER