Contactin-associated protein-like 2 (IPR029831)

Short name: Caspr2

Overlapping homologous superfamilies


Family relationships



The NCP family (for Neurexin-IV/Caspr/Paranodin) represents a distinct subgroup of the neurexins that includes mammalian Caspr (Contactin associated protein, also known as Paranodin), Caspr2, Caspr3, Caspr4 and Caspr5, and Drosophila Neurexin-IV. Both the neurexins and members of the NCP subgroup mediate cell-cell interactions. However, while the neurexins are thought to mediate the interactions between neurons, NCP proteins mediate neuron-glial interactions and in invertebrates, glial-glial contact [PMID: 11395000].

Caspr2 is localised at the juxtaparanodal region (JXP) of myelinated axons and associates with K+ channels [PMID: 10624965]. Caspr2 serves as a membrane scaffold that retains the K+ channels at the JXP [PMID: 19109503]. In humans, Caspr2 has an earlier organisational function in developing neurons that is essential for neural circuit assembly [PMID: 23074245].

GO terms

Biological Process

GO:0071205 protein localization to juxtaparanode region of axon

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.