Transcription factor JunB (IPR029822)
Short name: JunB
Overlapping homologous superfamilies
- Transcription factor Jun (IPR002112)
- Transcription factor JunB (IPR029822)
Transcription factor JunB is a member of the transcription factor activator protein (AP)-1 family, comprising Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF (ATFa, ATF-2 and ATF-3) and JDP (JDP-1 and JDP-2) family members [PMID: 15564374]. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes [PMID: 12424143]. JunB may serve as a biomarkers for prognosis of breast cancer [PMID: 24073962].
AP-1 proteins have a alpha-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif [PMID: 23787991]. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3') [PMID: 15564374]. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions [PMID: 15564374].
- PTHR11462:SF37 (PTHR11462:SF37)