Coagulation factor V (IPR029821)

Short name: Factor_V

Family relationships



Coagulation factor V plays an essential role in hemostasis. Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage. Upon thrombin activation, the B-domain is released and the active factor Va is formed by the heavy (A1-A2) and light chains (A3-C1-C2). The active factor Va functions as an essential cofactor to factor Xa in the conversion of prothrombin to thrombin during coagulation [PMID: 10097286]. The absence or dysfunction of factor Va leads to hemorrhagic diseases [PMID: 8900278, PMID: 15725905]. A factor V genetic mutation (factor VLEIDEN) causes an increased tendency to form abnormal blood clots in blood vessels (venous thrombosis) [PMID: 9252393].

The non-catalytic subunits of some snake venom prothrombin activators are functionally similar to blood coagulation factor V. They serve as a critical cofactor for the prothrombinase activity of the catalytic subunit, which is similar to the blood coagulation factor X [PMID: 3531198, PMID: 12362232].

GO terms

Biological Process

GO:0007596 blood coagulation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.