Basic leucine zipper transcriptional factor ATF-like (IPR029820)

Short name: BATF

Overlapping homologous superfamilies


Family relationships


Basic leucine zipper transcriptional factor ATF-like (BATF) is a transcription factor that dimerises with Jun class factors to bind AP-1 DNA sites [PMID: 12809553]. It does not only inhibit AP-1-driven transcription, but also has positive transcriptional activities in dendritic cells, B cells and T cells through its interaction with members of the interferon-regulatory factor (IRF) family [PMID: 23787991]. BATF controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells [PMID: 23787991].

GO terms

Biological Process

GO:0030154 cell differentiation
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.