Pathways & interactions
Jun dimerization protein 2 (IPR029819)
Short name: JDP2
Overlapping homologous superfamilies
- AP-1 transcription factor (IPR000837)
- Jun dimerization protein 2 (IPR029819)
Jun dimerization protein 2 (JDP2) regulates the AP-1-mediated activation of transcription [PMID: 16026868]. It can either form homodimers or form heterodimers with other AP-1 members, such as c-Jun, JunB, JunD, and ATF-2 [PMID: 21197464]. It binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences [PMID: 21197464]. JDP2 plays important roles in cellular differentiation, ageing and cancer [PMID: 17464331, PMID: 21197464].
- PTHR23351:SF10 (PTHR23351:SF10)