Family

Jun dimerization protein 2 (IPR029819)

Short name: JDP2

Overlapping homologous superfamilies

None.

Family relationships

Description

Jun dimerization protein 2 (JDP2) regulates the AP-1-mediated activation of transcription [PMID: 16026868]. It can either form homodimers or form heterodimers with other AP-1 members, such as c-Jun, JunB, JunD, and ATF-2 [PMID: 21197464]. It binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences [PMID: 21197464]. JDP2 plays important roles in cellular differentiation, ageing and cancer [PMID: 17464331, PMID: 21197464].

GO terms

Biological Process

GO:0031063 regulation of histone deacetylation
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER