Platelet-derived growth factor C (IPR029817)

Short name: PDGF-C

Overlapping homologous superfamilies

Family relationships



Platelet-derived growth factor C (PDGF-C) is a pleiotropic molecule with an important role in the regulation of embryonic development, cell proliferation, migration and survival [PMID: 10960785, PMID: 24421315, PMID: 16279938]. It also plays an important role in angiogenesis and neurovascular interaction [PMID: 24612214, PMID: 23714575].

PDGF-C contains an N-terminal CUB domain and a C-terminal domain with homology to members of the PDGF family. PDGF-C is secreted in a latent form. The CUB domain of PDGF-C has to be cleaved extacellularly to make the C-terminal growth factor domain active. After the cleavage, the growth factor domain is able to bind and activate PDGF receptors [PMID: 10806482, PMID: 11297552]. Two proteases are capable of activating PDGF-C: plasmin and tissue plasminogen activator (tPA) [PMID: 18172073, PMID: 15372073, PMID: 17904120]. The CUB domain has mitogenic activity in coronary artery smooth muscle cells independent of the presence of its C-terminal growth factor domain, suggesting a possible biological activity of the CUB domain itself [PMID: 11854040].

GO terms

Biological Process

GO:0009790 embryo development
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation

Molecular Function

GO:0005161 platelet-derived growth factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.