c-Fos/v-Fos (IPR029816)

Short name: c-Fos/v-Fos

Family relationships


Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes [PMID: 12424143]. Fos protein family members are involved in rodent fibroblasts transformation [PMID: 10963134]. Fos protein family members form stable heterodimers with Jun proteins and thereby enhance their DNA-binding activity [PMID: 23904356].

This entry represents the c-Fos and v-Fos proteins. c-Fos is the human homologue of the retroviral oncogene v-Fos. c-Fos can regulate growth not only by its transcription-factor activity, but also through mechanisms independent of its genomic AP-1 activity. By association with particular enzymes, it can act as a cytoplasmic activator of the biosynthesis of lipids both in normal and pathological cellular processes [PMID: 24886961]. In the nucleus, where lipid synthesis also occurs, it binds to PI4P5K (phosphatidylinositol-4-monophosphate 5-kinase) and activates nuclear PtdIns(4,5)P2 synthesis in response to growth signals, which, in turn, promotes transcriptional changes [PMID: 24819416].

GO terms

Biological Process

GO:0006357 regulation of transcription from RNA polymerase II promoter

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.