cAMP-dependent transcription factor ATF-4 (IPR029811)

Short name: ATF4

Overlapping homologous superfamilies


Family relationships



ATF4 belongs to the ATF/cAMP-response element-binding protein family. It is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters [PMID: 8506317, PMID: 12202230]. It plays a crucial role in the adaptation to stresses by regulating the transcription of many genes [PMID: 23804767].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.