Pathways & interactions
cAMP-dependent transcription factor ATF-6 beta (IPR029809)
Short name: ATF6B
The unfolded protein response (UPR) is mediated by three ER membrane-bound proteins: double-stranded RNA-dependent protein kinase (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6) [PMID: 24242870]. ATF6 has two isoforms, alpha and beta; this entry represents the isoform beta.
ATF6 is a transcription factor that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER [PMID: 14699159]. It contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and its cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 11158310, PMID: 15665855].
ATF6-beta can be cleaved and generate a nuclear form that inhibits ATF6-alpha mediated ER stress response gene activation [PMID: 14973138, PMID: 17522056]. N-glycosylation of ATF6-beta is essential for its transcriptional repressor function to ATF6-alpha [PMID: 19693772].
- PTHR22952:SF168 (PTHR22952:SF168)