cAMP-responsive element-binding protein 3 (IPR029808)
Short name: Luman
Overlapping homologous superfamilies
cAMP-responsive element-binding protein 3 (CREB3, also known as Luman) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman [PMID: 24242870]. Members of OASIS family share protein sequence similarity with ATF6, which is involved in unfolded protein response (UPR). Luman is involved in astrocyte differentiation in mammals [PMID: 24242870].
Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 15665855].
No terms assigned in this category.
- PTHR22952:SF100 (PTHR22952:SF100)