cAMP-responsive element-binding protein 3-like protein 4 (IPR029807)

Short name: CREB4

Overlapping homologous superfamilies


Family relationships



cAMP-responsive element-binding protein 3-like protein 4 (also known as CREB4 protein) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman [PMID: 24242870]. Members of OASIS family share protein sequence similarity with ATF6, which is involved in unfolded protein response (UPR). CREB4 is involved in astrocyte differentiation in mammals [PMID: 24242870].

Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 15665855].

GO terms

Biological Process

GO:0030968 endoplasmic reticulum unfolded protein response
GO:0045944 positive regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity
GO:0035497 cAMP response element binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.