Pathways & interactions
cAMP-responsive element-binding protein 3-like protein 1 (IPR029805)
Short name: OASIS
- cAMP response element binding (CREB) protein (IPR001630)
- cAMP-responsive element-binding protein 3-like protein 1 (IPR029805)
cAMP-responsive element-binding protein 3-like protein 1 (also known as OASIS protein) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman [PMID: 24242870]. Members of OASIS family share protein sequence similarity with ATF6, which is involved in unfolded protein response (UPR). OASIS protein is involved in the differentiation of osteoblasts and goblet cells in the large intestine as well as in astrocytes [PMID: 24242870].
Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 15665855].
No terms assigned in this category.
- PTHR22952:SF24 (PTHR22952:SF24)