cAMP-responsive element-binding protein 3-like protein 1 (IPR029805)

Short name: OASIS

Family relationships


cAMP-responsive element-binding protein 3-like protein 1 (also known as OASIS protein) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman [PMID: 24242870]. Members of OASIS family share protein sequence similarity with ATF6, which is involved in unfolded protein response (UPR). OASIS protein is involved in the differentiation of osteoblasts and goblet cells in the large intestine as well as in astrocytes [PMID: 24242870].

Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 15665855].

GO terms

Biological Process

GO:0030968 endoplasmic reticulum unfolded protein response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Molecular Function

GO:0035497 cAMP response element binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.