cAMP-responsive element-binding protein 3-like protein 2 (IPR029804)
Short name: BBF2H7
Overlapping homologous superfamilies
cAMP-responsive element-binding protein 3-like protein 2 (also known as BBF2H7) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman [PMID: 24242870]. Members of OASIS family share protein sequence similarity with ATF6, which is involved in unfolded protein response (UPR). Despite the structural similarities with ATF6, differences in activating stimuli, tissue distribution, and response element binding indicate specialised functions of each member of the OASIS family on regulating the UPR in specific organs and tissues [PMID: 17178827]. BBF2H7 is involved in the proliferation and differentiation of chondrocytes [PMID: 19767744, PMID: 24332809].
Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 15665855].
No terms assigned in this category.
- PTHR22952:SF96 (PTHR22952:SF96)