cAMP-responsive element-binding protein 3-like protein 2 (IPR029804)

Short name: BBF2H7

Overlapping homologous superfamilies


Family relationships



cAMP-responsive element-binding protein 3-like protein 2 (also known as BBF2H7) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman [PMID: 24242870]. Members of OASIS family share protein sequence similarity with ATF6, which is involved in unfolded protein response (UPR). Despite the structural similarities with ATF6, differences in activating stimuli, tissue distribution, and response element binding indicate specialised functions of each member of the OASIS family on regulating the UPR in specific organs and tissues [PMID: 17178827]. BBF2H7 is involved in the proliferation and differentiation of chondrocytes [PMID: 19767744, PMID: 24332809].

Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 15665855].

GO terms

Biological Process

GO:0030968 endoplasmic reticulum unfolded protein response
GO:0045944 positive regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA binding transcription factor activity
GO:0035497 cAMP response element binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.