cAMP-dependent transcription factor ATF-6 alpha (IPR029801)
Short name: ATF6A
The unfolded protein response (UPR) is mediated by three ER membrane-bound proteins: double-stranded RNA-dependent protein kinase (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6) [PMID: 24242870]. This entry represents the isoform alpha of ATF6.
ATF6 is a transcription factor that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER [PMID: 14699159]. It contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and its cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [PMID: 11158310, PMID: 15665855].
- PTHR22952:SF116 (PTHR22952:SF116)