Axin-1 (IPR029797)

Short name: AXIN1

Overlapping homologous superfamilies


Family relationships



Axin-1 (axis inhibition protein 1) is a scaffold protein that is involved in many signalling pathways, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades [PMID: 18316368, PMID: 15067197]. It controls many biological processes ranging from sugar intake, cell proliferation, and organ development to cell death [PMID: 15067197].

Mutations in Axin-1 gene cause hepatocellular carcinoma (HCC), a primary malignant neoplasm of epithelial liver cells [PMID: 10700176], and caudal duplication anomaly (CADUA), a condition characterised by the occurrence of duplications of different organs in the caudal region [PMID: 10700176].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0030159 receptor signaling complex scaffold activity

Cellular Component

GO:0030877 beta-catenin destruction complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.