Iron regulatory protein 1 (IPR029784)

Short name: IRE-BP1

Overlapping homologous superfamilies

Family relationships


In mammals, iron regulatory proteins (IRPs) 1 and 2 posttranscriptionally regulate expression of genes involved in iron metabolism by binding mRNA motifs called iron responsive elements (IREs) [PMID: 20603012]. IRP1 is a bifunctional protein that also has aconitase activity. IRP1 mostly exists in a non-IRE-binding, [4Fe-4S] cluster aconitase form which predominates when iron levels are normal; but if levels drop sufficiently the disassembly of the [4Fe-4S]-cluster occurs and there is a change of conformation to the IRE-binding form. On the other hand, IRP2 does not assemble an Fe-S cluster, lacks aconitase activity, and spontaneously binds IREs [PMID: 21566147]. Since IRP1 is predominantly in the enzymatic cytoplasmic aconitase form, it is IRP2 that acts as the major metabolic regulator that maintains iron homeostasis [PMID: 16850017].

This entry represents iron regulatory protein 1, also known as iron-responsive element-binding protein 1 (IRE-BP1) or cytoplasmic aconitate hydratase [PMID: 8041788].

GO terms

Biological Process

GO:0006879 cellular iron ion homeostasis
GO:0010040 response to iron(II) ion

Molecular Function

GO:0051539 4 iron, 4 sulfur cluster binding
GO:0003994 aconitate hydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.