Family

Tectonin beta-propeller repeat-containing protein 2 (IPR029772)

Short name: TECPR2

Family relationships

None.

Description

Tectonin beta-propeller repeat-containing protein 2 probably plays a role as positive regulator of autophagy [PMID: 23176824]. Mutations in TECPR2 gene cause Spastic paraplegia 49, autosomal recessive (SPG49), which is a form of spastic paraplegia, a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limb [PMID: 23176824].

This entry also includes WD repeat-containing protein CG11141 from Drosophila melanogaster. The function of CG11141 is not clear.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER