Leucine-rich repeat-containing protein 16A (IPR029764)

Short name: CARMIL1

Overlapping homologous superfamilies


Family relationships



This entry represents leucine-rich repeat-containing protein 16A (LRRC16A). In humans it is also known as CARMIL1, which belongs to the CARMIL (capping protein, Arp2/3 and Myosin-I linker) family. CARMIL family members are potential regulators of actin capping proteins, which control the polymerisation of actin filaments by capping their barbed ends [PMID: 22411988, PMID: 16054028]. CARMIL1 is essential for cell migration and may control lamellipodial actin assembly via effects on Trio and Rac1 [PMID: 19846667, PMID: 23904264].

GO terms

Biological Process

GO:0051638 barbed-end actin filament uncapping
GO:2000813 negative regulation of barbed-end actin filament capping
GO:0030335 positive regulation of cell migration
GO:1902745 positive regulation of lamellipodium organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030027 lamellipodium

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.