Conserved Site

Glutathione peroxidase conserved site (IPR029760)

Short name: GPX_CS

Description

Glutathione peroxidase (GSHPx) (EC:1.11.1.9) is an enzyme that catalyses the reduction of hydroxyperoxides by glutathione [, PMID: 7565867]. Its main function is to protect against the damaging effect of endogenously formed hydroxyperoxides.

In higher vertebrates, several forms of GSHPx are known, including a ubiquitous cytosolic form (GSHPx-1), a gastrointestinal cytosolic form (GSHPx-GI), a plasma secreted form (GSHPx-P), and an epididymal secretory form (GSHPx-EP). In addition to these characterised forms, the sequence of a protein of unknown function [PMID: 2771650] has been shown to be evolutionary related to those of GSHPx's.

Escherichia coli protein btuE, a periplasmic protein involved in the transport of vitamin B12, is also evolutionary related to GSHPx's; the significance of this relationship is not yet clear. Escherichia coli protein btuE, a periplasmic protein involved in the transport of vitamin B12, is also evolutionary related to GSHPx's; the significance of this relationship is not yet clear.

This conserved site consists of a octapeptide located in the central section of these proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns