Conserved Site

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site (IPR029753)

Short name: D-isomer_DH_CS

Description

A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related [PMID: 2692566, PMID: 1567457, PMID: 1840590, PMID: 8120891]. All these enzymes have similar enzymatic activities and are structurally related.

This entry includes two conserved sites that contain a number of conserved charged residues, some of which may play a role in the catalytic mechanism.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns