Membrane metallo-endopeptidase-like 1 (IPR029735)

Short name: MMEL1

Overlapping homologous superfamilies


Family relationships

  • Peptidase M13 (IPR000718)
    • Membrane metallo-endopeptidase-like 1 (IPR029735)


Membrane metallo-endopeptidase-like 1 (MMEL1, also known as Neprilysin 2) is a metalloprotease involved in sperm function and neuropeptide degradation [PMID: 11278416, PMID: 18571334]. The expression of MMEL1 is limited to the testis and CNS [PMID: 10814502]. In humans, it is involved in beta-amyloid (Abeta) degradation and hence associated with Alzheimer's disease [PMID: 18571334].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.