Endothelin-converting enzyme 2 (IPR029733)

Short name: ECE2

Family relationships

  • Peptidase M13 (IPR000718)
    • Endothelin-converting enzyme 2 (IPR029733)


Endothelin-converting enzyme 2 (ECE2) is a non-classical neuropeptide processing enzyme that processes various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides [PMID: 21972895, PMID: 12560336]. ECE2 was named for its ability of generating the potent vasoconstrictor endothelin-1 (ET-1) from its precursor big-ET-1 [PMID: 7797512]. ECE-2 KO mice show increased amyloid beta-protein accumulation in the brain and exhibit abnormal responses to morphine and altered peptide levels in the spinal cord [PMID: 12464614, PMID: 21972895].

GO terms

Biological Process

GO:0016486 peptide hormone processing

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.