Family

Neprilysin (IPR029727)

Short name: MME/CD10/NEP

Overlapping homologous superfamilies

None.

Family relationships

Description

Neprilysin (also known as MME, NEP or CD10) is an membrane metallo-endopeptidase acting on polypeptides of up to 30 amino acids. It degrades the amyloid beta-peptide (Abeta) in the central nervous system, which is associated with Alzheimer's disease [PMID: 15548496]. It was identified in leukemia as a tumour-specific antigen (common acute lymphoblastic leukemia antigen) and is used in cancer diagnosis [PMID: 21425402]. It plays an important role in inflammatory responses [PMID: 1717072]. In mammals, it is involved in mammary gland development [PMID: 21425402].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER