DNA ligase 4 (IPR029710)

Short name: LIG4

Overlapping homologous superfamilies


Family relationships


DNA ligase 4 (LIG4) is involved in DNA double-strand break repair [PMID: 12753583]. In higher eukaryotes it forms a complex with XRCC4, which is responsible for the ligation step during the DNA-PK-dependent non-homologous end joining (D-NHEJ) [PMID: 19604590, PMID: 11292837]. The Ku component of the DNA-PK (DNA-dependent protein kinase) complex contributes to the recruitment of the LIG4-XRCC4 complex at the DNA break site [PMID: 19604590].

GO terms

Biological Process

GO:0051103 DNA ligation involved in DNA repair
GO:0006281 DNA repair

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0003910 DNA ligase (ATP) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.