DNA polymerase epsilon catalytic subunit (IPR029703)

Short name: POL2

Overlapping homologous superfamilies


Family relationships


DNA polymerase epsilon catalytic subunit (also known as POL2) is a catalytic subunit of DNA polymerase epsilon, which is a a high-fidelity polymerase participating in chromosomal DNA replication [PMID: 24292646]. It contains both polymerase and 3'-5'-exonuclease domains [PMID: 24292646]. Its 3'-5'-exonuclease domain ensures a particularly low error rate [PMID: 24583393]. POL2 also plays a role in DNA repair and is linked to cancer [PMID: 24583393]. Its structure has been solved [PMID: 24733111].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0006260 DNA replication

Molecular Function

GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity

Cellular Component

GO:0008622 epsilon DNA polymerase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.