Geminin (IPR029697)

Short name: Geminin

Overlapping homologous superfamilies


Family relationships


Geminin inhibits DNA replication by preventing the recruitment of the MCM complex to form the pre-replication complex at the origin of replication [PMID: 12192004]. Geminin is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle [PMID: 9635433].

Geminin can also inhibit the DNA replication licensing factor Cdt1 and regulates cell proliferation and differentiation [PMID: 24064211]. Besides forming homodimers, Geminin can also form heterodimers with its homologue, Idas (also known as Multicilin) [PMID: 24064211]. The Idas-Geminin heterodimer binds Cdt1 less strongly than Geminin-Geminin [PMID: 24064211].

GO terms

Biological Process

GO:0008156 negative regulation of DNA replication
GO:0045786 negative regulation of cell cycle

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.