Short name: Geminin
Overlapping homologous superfamilies
- Geminin/Multicilin (IPR022786)
- Geminin (IPR029697)
Geminin inhibits DNA replication by preventing the recruitment of the MCM complex to form the pre-replication complex at the origin of replication [PMID: 12192004]. Geminin is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle [PMID: 9635433].
Geminin can also inhibit the DNA replication licensing factor Cdt1 and regulates cell proliferation and differentiation [PMID: 24064211]. Besides forming homodimers, Geminin can also form heterodimers with its homologue, Idas (also known as Multicilin) [PMID: 24064211]. The Idas-Geminin heterodimer binds Cdt1 less strongly than Geminin-Geminin [PMID: 24064211].
- PTHR13372:SF4 (PTHR13372:SF4)