Schlafen family (IPR029684)

Short name: Schlafen

Overlapping homologous superfamilies


Family relationships


The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [PMID: 23570387]. Mouse and human SLFN proteins are regulated by interferons (IFNs) [PMID: 23570387]. All SLFNs contain a divergent AAA domain and an unique Slfn box adjacent to the AAA domain. This divergent AAA domain may have a function of GTP/ATP binding. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [PMID: 15351786, PMID: 18355440, PMID: 23570387]:

  • Group1: Slfn1, Slfn2, and Slfn Like 1.
  • Group2: Slfn3, Slfn4 and Slfn12.
  • Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.

Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases [PMID: 18355440].

This entry also includes orthopoxvirus sequences. Analyses indicate that a member of the Schlafen family was horizontally transferred from murine rodents to orthopoxviruses, where it is hypothesised to play a role in allowing the virus to survive host immune defense mechanisms [PMID: 19619625].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.