Family

Schlafen family member 11 (IPR029682)

Short name: SLFN11

Family relationships

Description

The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [PMID: 23570387]. Mouse and human SLFN proteins are regulated by interferons (IFNs) [PMID: 23570387]. All SLFNs contain a divergent AAA domain and an unique Slfn box adjacent to the AAA domain. This divergent AAA domain may have a function of GTP/ATP binding. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [PMID: 15351786, PMID: 18355440, PMID: 23570387]:

  • Group1: Slfn1, Slfn2, and Slfn Like 1.
  • Group2: Slfn3, Slfn4 and Slfn12.
  • Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.

Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases [PMID: 18355440].

Slfn11 is an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. It specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by inhibiting the expression of viral proteins in a codon-usage-dependent manner. Slfn11 binds transfer RNA and counteracts changes in the tRNA pool elicited by the presence of HIV [PMID: 23000900, PMID: 23045266]. In addition to its antiviral properties, Slfn11 has been shown to have an important role in sensitising malignant cells to topoisomerase inhibitors, as well as alkylating agents and other DNA-damaging agents [PMID: 22927417].

GO terms

Biological Process

GO:0051607 defense response to virus
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Molecular Function

GO:0000049 tRNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER