Ninein (IPR029664)

Short name: NIN

Overlapping homologous superfamilies


Family relationships



Ninein is a centrosomal protein required in positioning and anchoring the microtubule minus-end in epithelial cells [PMID: 15190203]. In human apical progenitor cells, it plays an essential role in cell cycle-dependent nuclear movement (interkinetic nuclear migration) by connecting microtubules to the centrosome [PMID: 23862022].

Mutations in ninein gene causes Seckel syndrome 7 (SCKL7), which is a rare autosomal recessive disorder characterised by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation [PMID: 22933543].

GO terms

Biological Process

GO:0034454 microtubule anchoring at centrosome

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005813 centrosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.