NADPH oxidase 1 (IPR029650)

Short name: NOX1

Overlapping homologous superfamilies


Family relationships


ADPH oxidase 1 (NOX1) is a NADPH oxidase that generates superoxide [PMID: 17275676]. It is involved in several cell functions such as proliferation, vascular contraction, host defence, and cytoskeletal remodelling [PMID: 24792722]. It requires small GTPase Rac, Noxa1 and Noxo1 for its activation [PMID: 23322165]. It can be regulated by betaPix through Rac activation [PMID: 24792722].

GO terms

Biological Process

GO:0042554 superoxide anion generation

Molecular Function

GO:0016175 superoxide-generating NADPH oxidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.