Ras guanyl-releasing protein 1/3 (IPR029645)

Short name: RASGRP1/RASGRP3

Overlapping homologous superfamilies

Family relationships


Guanine nucleotide exchange factors (GEFs) couple extracellular stimuli to Ras protein activation [PMID: 10934204]. Ras guanyl-releasing protein 3 (RasGRP3) is an activator for H-Ras, R-Ras and Ras-associated protein-1/2 [PMID: 21602881]. Its expression has been linked to several cancers [PMID: 21602881, PMID: 24779681, PMID: 20876802].

RasGRP1 acts downstream of TCR (T cell antigen receptor). Human T cell adapter protein SKAP55 (Src kinase-associated phosphoprotein of 55 kDa) binds to RasGRP1 and modulates signal transduction from the TCR to Ras [PMID: 17658605, PMID: 23506953]. Both RasGRP1 and RasGRP3 act downstream of BCR (B cell receptor) [PMID: 16301621].

Additionally, RasGRP1 has a role in mast cell function and IgE-mediated allergic response [PMID: 17190838]. RasGRP1 knockout mice are less susceptible to skin tumorigenesis [PMID: 20308057, PMID: 24464785]. The RasGRP1 gene has been identified as a susceptibility locus for the risk of type 1 and 2 diabetes in humans [PMID: 19465406, PMID: 22961080].

GO terms

Biological Process

GO:0007265 Ras protein signal transduction
GO:0043087 regulation of GTPase activity

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.