Calpain-1 (IPR029643)

Short name: CAPN1

Overlapping homologous superfamilies

Family relationships


Calpain-1 catalytic subunit (CAPN1, also known as mu-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [PMID: 12843408, PMID: 24085852]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28kDa) encoded by the gene Capn4 [PMID: 18515801]. Calpain-1 plays a role in regulating IgE-mediated mast cell activation [PMID: 24760147]. Calpain-1 is also involved in mammary gland remodelling [PMID: 24467364].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0005509 calcium ion binding
GO:0004198 calcium-dependent cysteine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.