Anaphase-promoting complex subunit 16 (IPR029641)

Short name: APC16

Overlapping homologous superfamilies


Family relationships



The anaphase promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C consists of thirteen different subunits and, in somatic cells, has two co-activators: Cdc20 and Cdh1 (also known as Fzr1), which associate with the APC/C core at defined stages of the cell cycle. APC/C is only active between metaphase and the end of the next G1 phase. During this time, APC/CCdc20 initiates anaphase and mitotic exit, while APC/CCdh1 contributes to mitotic exit and establishment of a stable G1 state [PMID: 23466868].

This entry represents the APC/C subunit 16 [PMID: 20392738].

GO terms

Biological Process

GO:0007049 cell cycle
GO:0016567 protein ubiquitination

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005680 anaphase-promoting complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.