Transient receptor potential cation channel subfamily M member 7 (IPR029601)

Short name: TRPM7

Overlapping homologous superfamilies


Family relationships



The TRPM subfamily of mammalian TRP channels includes TRPM7, which is a bifunctional molecule consisting of a TRP ion channel fused to a serine/threonine-protein kinase domain. It conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations [PMID: 24855944]. The kinase domain is proteolytically cleaved from the channel domain in a cell-type-specific manner, with the cleaved kinase fragments translocating to the nucleus and binding multiple components of chromatin-remodeling complexes [PMID: 24855944]. TRPM7 plays a prominent role in cellular and systemic magnesium homeostasis, and is a key player in embryonic development, global ischemia, cardiovascular disease, and cancer [PMID: 24756720].

GO terms

Biological Process

GO:0006812 cation transport
GO:0010961 cellular magnesium ion homeostasis

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.