Eosinophil peroxidase (IPR029599)

Short name: EPX/EPO

Overlapping homologous superfamilies

Family relationships


Eosinophil peroxidase (EPX or EPO) is an eosinophil-derived granule protein that utilises H2O2 as an oxidising substrate to generate potent oxidising species. This mechanism is used by eosinophils to kill parasites and microbes [PMID: 24802755, PMID: 7068848]. Besides using bromide as substrates to generate hypobromite (hypobromous acid), EPX can also oxidise thiocyanate (SCN-) ions to generate HOSCN-, which may induce the prothrombotic and proinflammatory endothelial and endocardial phenotypes responsible for thrombotic complications in the hypereosinophilic syndrome (HES) [PMID: 24802755]. EPX is involved in both anti-inflammatory and pro-inflammatory activities [PMID: 6281334, PMID: 6987310]. It may also play an important role through the production of reactive brominating species in asthma [PMID: 12208372, PMID: 10811853]. It is required for eosinophilopoiesis in mice [PMID: 23736699].

GO terms

Biological Process

GO:0006952 defense response

Molecular Function

GO:0004601 peroxidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.