Transient receptor potential cation channel subfamily M member 6 (IPR029597)

Short name: TRPM6

Overlapping homologous superfamilies


Family relationships



The TRPM subfamily of TRP channels includes TRPM6, which is a bifunctional protein comprising a TRP cation channel segment ion channel fused to a kinase domain with homology to the family of atypical alpha kinases [PMID: 17481860]. The TRPM6 channel kinase plays a central role in systemic Mg(2+) homeostasis, and loss-of-function mutations in the human TRPM6 gene give rise to hypomagnesemia with secondary hypocalcemia (HSH) [PMID: 24756719]. TRPM6 may have a role in neural tube closure during development, since mice with TRPM6 gene defects show neural tube defects and embryonic mortality [PMID: 19692351].

GO terms

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0005261 cation channel activity
GO:0004674 protein serine/threonine kinase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.