Dual oxidase 1/Duox (IPR029595)

Short name: DUOX1/Duox

Overlapping homologous superfamilies


Family relationships


This entry includes dual oxidase 1 (DUOX1) from mammals and Duox from fruit flies. DUOX1 and DUOX2 are isoenzymes that belong to the family of NADPH oxidases (Nox) [PMID: 19144650]. They function as calcium-dependent NADPH oxidases producing hydrogen peroxide (H2O2) necessary for thyroid hormone biosynthesis [PMID: 22612456]. Duox is found indispensable for gut antimicrobial activities in fruit flies [PMID: 16272120].

GO terms

Biological Process

GO:0050665 hydrogen peroxide biosynthetic process

Molecular Function

GO:0016174 NAD(P)H oxidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.