Transient receptor potential cation channel subfamily M member 2 (IPR029594)

Short name: TRPM2

Overlapping homologous superfamilies


Family relationships



The TRPM subfamily of mammalian TRP channels includes TRPM2, which has both Ca(2+)-permeable nonselective ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity [PMID: 24756715]. TRPM2 channels are embedded in the plasma membrane and/or lysosomal compartments and are activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca(2+) [PMID: 24756715]. They are also activated by oxidative stress, and confer susceptibility to cell death [PMID: 12594222]. TRPM2 proteins are widely expressed in a range of tissues, including the brain, immune system, endocrine cells, and endothelia. They are involved in a variety of functions, including cytokine production, insulin release, cell motility and cell death [PMID: 21135052].

GO terms

Biological Process

GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0006979 response to oxidative stress

Molecular Function

GO:0047631 ADP-ribose diphosphatase activity
GO:0005261 cation channel activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.