SHC-transforming protein 3 (IPR029593)

Short name: Shc3/ShcC/N-Shc

Overlapping homologous superfamilies


Family relationships



The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway [PMID: 11607835]. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [PMID: 8760305].

Shc3 (also known as NShc from neuronal Shc) mediates neurotrophin and other neuronal signallings in the central nervous system [PMID: 8808684, PMID: 15716419].

GO terms

Biological Process

GO:0007417 central nervous system development
GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.